If you’re looking for a supplement to lower your A1c, berberine, may be your best bet. One meta-analysis found 500-1,500 mg of berberine daily to be equally effective at lowering blood glucose as 1500 mg of metformin and 4 g of glibenclamide - two medications commonly prescribed for blood sugar control [1
]. The effectiveness of berberine supplementation was measured by how well the drugs reduced biomarkers of type II diabetes, including fasting blood glucose and A1c.
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For the purpose of reducing blood sugar and HbA1c, human and animal research suggests 1500 mg of berberine daily, split into three (500 mg) doses throughout the day, with a meal or shortly after to maximize the potential benefit on blood glucose after eating [2
Although berberine supplementation may be effective for lowering A1c, it is still less substantiated than most prescription medications and warrants more research, specifically in regards to its long-term effects. Moreover, diet is also an important component of component of reducing your blood sugar levels and should be considered for lowering A1c.