HomeBiomarkersLDL cholesterol overview LDL Cholesterol: 105 mg/dL

LDL Cholesterol: 105 mg/dL

What does an LDL level of 105 mean? Are there any symptoms associated with this level?

A level of 105 mg/dL is considered elevated. Although cholesterol serves several important functions, elevated LDL cholesterol may put you at greater risk for heart disease.
Elevated LDL cholesterol doesn’t have symptoms, which is why it’s important to know your levels. Lowering them will lower your risk of developing heart disease and other health issues. 
If you already have heart disease, lowering your cholesterol can reduce your odds of serious complications, like a heart attack or stroke. 

Factors that could contribute to a level of 105: 

  • Diet: Diets that are high in saturated fats, trans fats, added sugar, and low in fiber can cause LDL cholesterol to rise.
  • Weight. Being overweight also tends to increase cholesterol levels, including LDL cholesterol. 
  • Physical inactivity. A sedentary lifestyle can increase LDL (bad) cholesterol and lower HDL (good) cholesterol levels. 
  • Smoking. Smoking lowers your HDL (good) cholesterol which can contribute to a higher level of LDL (bad) cholesterol.
  • Medications: Some medications can increase cholesterol levels. These include:  corticosteroids, beta-blockers, thiazide diuretics, antivirals, retinoids, and growth hormones.
  • Diseases: Certain diseases like chronic kidney disease, diabetes, and HIV/AIDS can elevate total cholesterol and LDL.
  • Age and Sex: Premenopausal women tend to have lower total cholesterol levels than men of the same age. However, cholesterol levels tend to increase with age, in both women and men. After the age of menopause, women's LDL (bad) cholesterol levels tend to rise.
  • Genetics (heredity): High blood cholesterol can run in families. This is because your genes partly determine how much cholesterol your body makes. 
  • Race. Certain races may have an increased risk of high blood cholesterol. For example, Blacks/African Americans typically have higher HDL and LDL cholesterol levels than Caucasians.

What to do if your level is 105?

Making changes to your diet and adopting healthier habits can help lower your LDL cholesterol level back into the optimal range (<100 mg/dL). Here are some things you can do to help lower your LDL cholesterol:
  • Eat fiber-rich foods such as veggies, fruit, whole grains, and legumes, daily for a total of 30-40g fiber/ day. 
  • Limit sources of refined carbs and added sugars such as soda, chips, candy, baked goods, sweetened yogurt, and ice cream. 
  • Avoid trans fats (partially hydrogenated oils) and reduce saturated fat intake to < 10% total calories. 
  • Eat small, fatty fish such as salmon, sardines, and trout, at least twice a week. 
  • Get 30-60 minutes of physical activity 5x/week. 
  • Incorporate plant sterols and stanols daily (2g) in the form of food or a supplement. 
  • Lose weight if you are overweight or obese.
  • Quit smoking if you smoke.
  • If you have diabetes, achieve and maintain good blood sugar control (HbA1c).

Medications and supplements used to improve results

If diet and lifestyle changes are not enough to lower your LDL cholesterol, medications and supplements can help lower your level into a safer range.

Medications

Medications are typically prescribed if diet and lifestyle changes do not lower LDL cholesterol levels enough on their own. Some common cholesterol medications include:
  • Statins: Statins (including atorvastatin, simvastatin, and rosuvastatin) reduce cholesterol production in your liver. Because they typically need to be taken for life, statins are only prescribed if diet and lifestyle changes aren’t enough [3].
  • Ezetimibe can be helpful for those with familial hypercholesterolemia and/or who have side effects with statins. 
  • Bile acid sequestrants: These medications block cholesterol-rich bile acid from being absorbed into the bloodstream and can be prescribed in place of or in addition to a statin. 
  • PCSK9 inhibitors: This medicine is injected under your skin every 2 or 4 weeks and may be prescribed with a statin if you are at high risk of heart attack or stroke, or have familial hypercholesterolemia.
  • Lomitapide: Typically prescribed if you have familial hypercholesterolemia. Lomitapide requires liver enzyme monitoring as it can cause liver damage and is commonly taken with vitamin E.

Supplements

  • Plant sterols and stanols: Found in plant cell membranes, plant sterols and stanols (also called phytosterols) are similar in structure to cholesterol in the body and block dietary cholesterol from being absorbed. Phytosterols can be found in small quantities in vegetable oils, nuts, legumes, whole grains, fruits, and vegetables, however, the average daily intake (500 mg)  is typically not enough to lower cholesterol. Studies show consuming 2000 mg (2 g) of plant sterol and stanols daily from diet and/or supplements to be most effective [4]. Plant sterol and stanol supplements are taken before or with meals can help lower total cholesterol in parallel with other recommended diet and lifestyle changes [4]. 
  • Beta-glucan: Beta-glucan is a form of soluble fiber that has been shown to help lower cholesterol levels. It’s found naturally in whole grains like barley, oats, rye, and wheat, mushrooms, and seaweed, and is also available as a nutritional supplement. For cholesterol-lowering benefits, consume 3-7 g/day from your diet and/or a supplement.
  • Psyllium: Another type of soluble fiber made from the husk of psyllium seeds, psyllium is good for digestive health and regularity, and can also be helpful in lowering cholesterol. Psyllium supplements are sold in powder form and can help reduce lipid levels when taken daily at a dose of 8-12g/day. 
  • Alpha-lipoic acid: A potent antioxidant made in the body, alpha lipoic acid is also found in foods including carrots, beets, spinach, broccoli, potatoes, and red meat. Research indicates that 600 mg/day of alpha-lipoic acid from your diet and/or a supplement may help lower total cholesterol and LDL (bad) cholesterol [8]. 
  • Bergamot extract: Bergamot is a citrus fruit that has long been used for medicinal purposes. Taking bergamot extract (made from the juice of the fruit) seems to lower cholesterol and triglyceride levels in adults with high cholesterol [9,10]. One study suggests taking bergamot extract daily for a month may be as effective as taking a low dose of the cholesterol-lowering drug called rosuvastatin (Crestor) [10]. A recent research review indicates that 1000 mg/day may be most effective for lowering cholesterol. 
  • Green tea extract: Green tea extract is a natural supplement made from the leaves of the Camellia sinensis plant that has been shown to help lower LDL (bad) and total cholesterol [11]. A daily dose of 400 mg may help lower your cholesterol but check with your doctor first as green tea extract can interact with certain medications, including beta-blockers and blood thinners. In addition, green tea extract may also have a stimulant effect.
  • Berberine: A compound extracted from a variety of medicinal herbs, some studies suggest berberine can reduce LDL (bad) cholesterol and triglycerides in type 2 diabetics, as well as slightly increase HDL (good) cholesterol [12]. The standard dose of berberine is 900-2000 mg/day (divided into 3-4 doses), taken with or just after a meal.

References

  1. Cholesterol Levels: What You Need to Know. (n.d.). U.S. National Library of Medicine | NIH. Retrieved September 9, 2021, from https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html
  2. Carotid Artery Disease. (n.d.). National Heart, Lung, and Blood Institute | NIH. Retrieved September 9, 2021, from https://www.nhlbi.nih.gov/health-topics/carotid-artery-disease
  3. High cholesterol. (n.d.). NHS Inform. Retrieved September 9, 2021, from https://www.nhsinform.scot/illnesses-and-conditions/blood-and-lymph/high-cholesterol
  4. Racette, S. B., Lin, X., Lefevre, M., Spearie, C. A., Most, M. M., Ma, L., & Ostlund, R. E., Jr (2010). Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. The American journal of clinical nutrition, 91(1), 32–38. https://doi.org/10.3945/ajcn.2009.28070
  5. Cholesterol: Types, Tests, Treatments, Prevention. (2020, July 31). Cleveland Clinic. https://my.clevelandclinic.org/health/articles/11920-cholesterol-numbers-what-do-they-mean
  6. Blood Cholesterol | NHLBI, NIH. (2021, January 4). National Institutes of Health. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol
  7. LDL: The “Bad” Cholesterol. (n.d.). National Institutes of Health. Retrieved September 22, 2021, from https://medlineplus.gov/ldlthebadcholesterol.html
  8. Mousavi, S. M., Shab-Bidar, S., Kord-Varkaneh, H., Khorshidi, M., & Djafarian, K. (2019). Effect of alpha-lipoic acid supplementation on lipid profile: A systematic review and meta-analysis of controlled clinical trials. Nutrition (Burbank, Los Angeles County, Calif.), 59, 121–130. https://doi.org/10.1016/j.nut.2018.08.004
  9. Cai, Y., Xing, G., Shen, T., Zhang, S., Rao, J., & Shi, R. (2017). Effects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo-controlled trial. Lipids in health and disease, 16(1), 251. https://doi.org/10.1186/s12944-017-0640-1
  10. Gliozzi, M., Walker, R., Muscoli, S., Vitale, C., Gratteri, S., Carresi, C., Musolino, V., Russo, V., Janda, E., Ragusa, S., Aloe, A., Palma, E., Muscoli, C., Romeo, F., & Mollace, V. (2013). Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. International journal of cardiology, 170(2), 140–145. https://doi.org/10.1016/j.ijcard.2013.08.125
  11. Xu, R., Yang, K., Li, S. et al. Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr J 19, 48 (2020). https://doi.org/10.1186/s12937-020-00557-5
  12. Berberine, Examine. (2021, May 5). Examine.com. https://examine.com/supplements/berberine/#